San Francisco 49ers vs. Los Angeles Rams prediction, pick, odds: Niners amped for rematch

“It’s frustrating and I really don’t think we have played together as a team, offense and defense, yet,” Niners star defensive end Nick Bosa said. “So we need to get clicking on all cylinders if we’re going to make a run this year.”

The 49ers also were 3-4 last season, further dropping to 3-5, before making their payoff run. That resurgence began with a 31-10 victory in Week 10 over the Rams.

The 49ers’ hope new addition Christian McCaffrey can trigger a repeat revival. In his first game with the team after a trade from the Carolina Panthers, the running back gained 38 yards on eight carries and had two catches for 24 yards in limited usage.

“It was a weird week for me and for them; I didn’t know what to expect,” said McCaffrey, who joined the 49ers last Friday. “… I think for me, mentally, this was just control what I can control and get rolling.”

The Rams have been trying to get rolling all season. With injuries on the offensive line, Los Angeles is coming off a much-needed bye week. It entered its downtime with a solid 24-10 victory over the Panthers, in a game that included McCaffrey.

But the Rams preceded that with a 22-10 loss to the Dallas Cowboys when Stafford was sacked five times and threw an interception. Los Angeles has scored 17.3 points per game, fourth from the bottom in the NFL.

Rams center Brian Allen (knee), who anchors the offensive line, did return to practice Wednesday, but was limited. He is expected to play.

“We know who they are,” Allen said of the 49ers. “We’re not scared of them. They’re not scared of us, obviously. It’s going to be a fight.”

Also back at practice for the Rams, although limited, was wide receiver Van Jefferson (knee), who hasn’t played this season. He is expected to see action Sunday.

“Obviously, he brings a big-play element, but I think Van is a complete receiver,” Rams coach Sean McVay said. “I think he showed that with the way he was progressing, really throughout last year and especially where he was at in training camp.”

While a 3-3 start to the season has been far below the Rams’ expectations, they did have an 0-3 stretch last November yet still made a championship run. At issue is a rushing attack that is second-worst in the NFL with 70.5 yards per game.