Los Angeles Chargers vs. Indianapolis Colts MNF preview, prediction, pick: Will injuries do in the Colts?

“This is never an easy decision,” Saturday said. “I think the world of Matt and he’s a pro’s pro and I appreciate the way he’s handled it. Obviously, not the season he expected, nor the Colts as a whole. Feel bad for Matt, but ultimately, I feel Nick gives us the best chance to win.”

Ryan has more than twice as many touchdown passes (381) as interceptions (183) in his 15-year NFL career, but he has 14 touchdown passes and 13 interceptions this season.

Foles won a Super Bowl with the Philadelphia Eagles in 2018-19 after replacing injured Carson Wentz in Week 14.

Chargers All-Pro safety Derwin James returned to practice on Thursday and was listed as limited on the injury report.

James sustained a quad injury in a loss to the Las Vegas Raiders on Dec. 4 and missed the past two games.

“We expect to play better with one of the top players in the league out there,” Chargers coach Brandon Staley said. “I think that will be a great infusion of leadership, production and energy.”

Staley said it’s satisfying that the Chargers have been able to win the past two games without James, but there’s a noticeable difference when he’s not on the field.

“One of the few defensive players that, when he is not in the game, we don’t have a very good record without him,” Staley said. “Our record got a little bit better, which, I think, is a good sign for our football team.”

Despite the collapse last weekend by the Colts, Staley said they aren’t a team to overlook.

“Indianapolis was up 33-0 last week in an NFL game,” Staley said. “That’s very difficult to do. The reason why they were is because they have a lot of good players and they have a lot of good coaches.”

The Chargers enter the weekend as the sixth seed in the AFC and can clinch a playoff berth with a win against Indianapolis and losses by the New York Jets, Raiders and Patriots.

Chargers defensive end Joey Bosa did not practice on Thursday and it does not appear he’ll be ready to return from a groin injury that has kept him out since Week 3. Los Angeles running back Austin Ekeler appears to have avoided injury after an MRI on his shoulder came back negative.

Chargers cornerback Kemon Hall (hamstring) did not practice Thursday. Indianapolis corner Kenny Moore II (ankle) and tight end Kylen Granson (ankle) missed practice Thursday.