Ole Gunnar Solskjaer’s side were beaten by City at this stage last season and will be keen to exact revenge as the Norwegian seeks his first trophy as United boss.
City have won this competition for the last three seasons and as defending champions remain the team to beat.
Manchester United have been handed a mouthwatering derby against Manchester City
City are defending champions in the Carabao Cup and remain the team to beat this season
United once again being paired with City in this competition at the semi-final stage means they are just the second pair of teams to meet in the League Cup semi-finals in consecutive seasons.
Arsenal and Tottenham went head-to-head in both the 2006-07 and 2007-08 seasons.
The other match-up sees Championship Brentford, who added Newcastle as a fourth Premier League scalp to reach the last four on Tuesday night, travelling north to take on Jose Mourinho’s Spurs following their 3-1 win at Stoke.
Harry Kane (right) fired Tottenham through and they were handed a more favourable draw
Manchester United v Manchester City
Tottenham v Brentford
Ties to be played w/c January 4
Gareth Bale, Ben Davies and Harry Kane were all on target for Mourinho’s side and they will need to beat Championship opposition once more if they are to reach the final.
It is a competition Mourinho is particularly fond of having won it four times already in his career – three times with Chelsea and once with Manchester United.
Tottenham last won the League Cup in 2008 and it has proven to be their only trophy in the last 12 years, increasing the pressure on Mourinho and his players to deliver silverware this season.
The semi-finals will be played in the week commencing January 4 and are now a one-off game, rather than the home and away format of previous seasons.
The decision to drop down to one leg, with Manchester United and Tottenham now boasting home advantage, has been implemented to reduce a fixture pile-up given the intense schedules clubs are juggling.
Championship Brentford travel to Tottenham as they target a fifth Premier League scalp