Los Angeles Chargers vs. San Francisco 49ers SNF prediction, pick, odds: Chargers eye fourth straight road win

“He feels a lot better and that counts for a lot,” Chargers coach Brandon Staley said. “I really felt he was playing (at Atlanta) the way he can play and was just really in control of the game plan. … I thought he made good adjustments and was a good decision maker and made fast decisions and played really well in the clutch.”

The Chargers’ issues on offense include injuries to the wide receivers as well as a disappointing rushing attack that has averaged 89.1 yards per game. Los Angeles is one of five teams rushing for less than 90 yards per game.

Receivers Keenan Allen (hamstring) and Mike Williams (ankle) did not practice Wednesday, with Staley insisting Allen is day-to-day. Linebackers Troy Reeder (ankle) and Amen Ogbongbemiga (groin) were limited. Defensive lineman Austin Johnson was lost for the season after he fractured his knee and sprained his MCL against the Falcons.

“He’s going to stay with us and he is going to be a key contributor, helping these guys throughout the rest of the season,” Staley said.

The 49ers expect to have Samuel back this week after he was a full participant in practice Wednesday. Samuel, who has two receiving TDs and one rushing, missed the Week 8 victory over the Rams with a hamstring injury.

Head coach Kyle Shanahan sounds comfortable giving Samuel a hefty workload Sunday, while combining him with new running back Christian McCaffrey for the first time.

“We’ve got five guys who can touch the ball so the more people have to worry about those five guys the better,” Shanahan said. “You have two guys (Samuel, McCaffrey) who are a little bit interchangeable at different positions but they both can play the other one’s position.

“It makes a little more space and it makes it a little bit more of a threat for whoever gets the ball in their hand.”

Linebacker Dre Greenlaw (calf) returned to practice Wednesday but was limited after also sitting out in Week 8. Defensive tackle Arik Armstead has a hairline fracture in his right leg that will force him to miss time.

Since taking over the quarterback position from an injured Trey Lance, Jimmy Garoppolo has been up to the task with 241.6 passing yards per game and 11 TDs with four interceptions, but the 49ers are just 3-3 in his six starts.

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